Reproduction Abstracts

Introduction: The anaphase-promoting complex (APC) is an E3-ubiquitin ligase responsible for regulated destruction of substrates at specific stages of the cell cycle. Two APC co-activators, Cdc20 and Cdh1, mediate the timing and selectivity of substrates recognition. Progression through meiosis in oocytes utilises the same molecular players, although the start–stop nature of the female meiosis invokes additional levels of regulation. Recently, we reported that Cdk1 and MA...